Every time Apple releases a major update people want to know if it is safe to install on their device. I'm not sure what internet urban legend has made people nervous about software updates, but it is a common concern amongst iPhone and iPad users. While it has been true that some updates have caused minor issues for older devices, Apple has always quickly resolved these problems with additional updates. As of right now there seems to be no reason anyone would not want to upgrade to iOS 10, however we won't officially know until the final version is released in the fall. Also don't forget, Apple now tests all its new features with developers and the public through its two beta programs. This helps avoid most potential problems with the final release.
The only users who should be concerned about upgrading their devices are those who own older hardware, such as the iPhone 5, iPhone 5c, iPad mini 2 and fourth-generation iPad. Sometimes the speed and performance of older iPhone and iPad models are affected because they are not equipped to handle newly introduced features. Apple typically issues performance updates specifically designed for older hardware after most major releases.
Also don't forget that a lot of older devices will not support most of the new features. For example, 3D Touch is only supported on newer models, like the iPhone 6s and 6s Plus. A lot of times this makes it pointless the upgrade older hardware. While the iPhone 4s supported iOS 9.0 it didn't support most of the features found in later updates.
You should be careful about any tips you receive on social media, especially if it is in the form of a meme. Internet trolls like to trick unsuspecting iPhone users into destroying their devices by making fake ads, such as the infamous iOS 7.0 waterproof gag of 2013. You can't charge your phone in a microwave or do anything else of the ridiculous things you may see on Facebook or Twitter. Stick to trusted blogs and websites, such as iPhoneFAQ.org, when looking for iPhone and iPad tricks or tips.
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As always, iPhone and iPad owners with jailbroken devices will want to avoid iOS 10 if they want to keep their tweaks and Cydia apps installed. There is currently no jailbreak for iOS 10.